Santhera outlines cuts, and they’re deep, as CMO hits the exit


Practically one month in the past, Santhera admitted defeat for its Duchenne muscular dystrophy (DMD) drug idebenone, culling this system.

On the time, Santhera mentioned {that a} “restructuring” was coming, with its focus now centered on one other DMD hopeful, vamorolone, in addition to lonodelestat, which is concentrating on lung illnesses equivalent to cystic fibrosis.

Vamorolone, a nonhormonal steroid modulator, is just not an inside program, however reasonably one which Santhera nabbed in August from ReveraGen BioPharma, and can possible show pivotal to its future.

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It’s at the moment in a make-or-break section Three trial that is because of ship top-line knowledge within the second quarter of 2021. Lonodelestat, in the meantime, is in section 1b in cystic fibrosis.

However with the main target now on these medicine and all scientific work on idebenone out the window, the Swiss biotech is taking the ax (PDF) to 50 staffers to save lots of money, lowering its staff all the way down to 47 full-timers.

On prime of this, Kristina Sjöblom Nygren, M.D., its chief medical officer and head of improvement, is leaving “for household causes and to pursue different alternatives,” based on a launch, which implies she is going to possible flip up some other place.

“The seek for a successor to safe a seamless transition has been initiated,” the biotech added in an announcement.

This may save the corporate round $10 million a 12 months, in addition to saving money by not engaged on idebenone (aka Puldysa). To assist keep afloat, it’s borrowed an additional $16 million. Altogether, it hopes it will see it proceed on to the six-month knowledge readout for vamorolone subsequent 12 months.

RELATED: Santhera flunks DMD section 3, prompting restructuring and withdrawal of approval software

“Shifting ahead as an organization with a deal with vamorolone, upon acquisition of world rights in all indications by way of agreements with Idorsia and ReveraGen and the termination of the Puldysa program, has pressured us to take tough choices however on the similar time has opened up new alternatives,” mentioned Dario Eklund, CEO of Santhera.

“Regretfully, we have now to let go of a lot of our valued colleagues and I thank all of them for his or her dedication and efforts to do the easiest for sufferers. Specifically and on behalf of the whole administration group, I want to thank Kristina, who has performed an essential function in shaping and executing our scientific improvement technique, for her helpful contributions to our Firm. We want her and others leaving all the very best for his or her future.”


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