Novo Nordisk cans experimental weight problems medication after success with later-stage meds


After seeing later stage trials come via in weight problems, Novo Nordisk is canning two tasks that have been aiming to assist scale back sufferers’ weight.

Particularly, the Danish drugmaker has terminated its section 1 GG-co-agonist (a glucagon-GLP-1 co-agonist) and tri-agonist tasks (a triple full agonist of the native human GLP-1, gastric inhibitory peptide and glucagon receptors), each of which have been designed to deal with weight problems.

Why have they acquired the ax? Novo mentioned they’re victims of the success of their two different meds, the authorised semaglutide (a.okay.a Ozempic), and one other investigational med, AM833, an amylin analogue.

Each have in latest months seen trial successes on their very own and as a combo remedy in treating weight problems, with a section 1 combo check in June exhibiting these receiving the very best dose of the medication misplaced a mean of 17.1% physique weight from a imply baseline physique weight of 94.6kg.

This follows on from the 4 trial section three program, often called STEP 1, 2, three and 4 , which over the summer season has additionally seen a collection of positives for the corporate for semaglutide by itself in opposition to a collection of targets together with placebo and intensive behavioural remedy, and in those that are chubby, overweight, or with sort 2 diabetes.

“Latest information from the section three improvement programme, STEP, for semaglutide in weight problems and the medical trials with AM833 as monotherapy and together with semaglutide have raised the innovation bar in weight problems care, which has led to a prioritisation inside the weight problems care improvement portfolio and termination of the [GG-co-agonist and tri-agonist] tasks,” Novo mentioned in its financials Thursday morning.

Novo’s gross sales have been up 8% by 7% at fixed alternate charges to DKK 63.9 billion. On the influence of COVID-19 on its trials, the pharma mentioned: “For ongoing trials, recruitment of latest sufferers is negatively impacted, however steadily bettering. It’s now potential to provoke new trials in sure nations.”


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